Cancer, melanoma genomes: A story we missed
Sunday, December 20th, 2009
I missed an important story last week, and so did most of the English-language news media on both sides of the Atlantic.
According to a story by Catharine Paddock for Medical News Today, researchers in England have sequenced the genomes of melanoma and small-cell lung cancer.
Thanks to Victor McElheny, former director of the Knight Fellowhips at MIT, for calling my attention to the story, which was based on research published in Nature last week.
“Both papers came largely from the Sanger Institute outside Cambridge, and got big play in London, little so far over here,” Vic wrote in an email. I’d challenge him on that a bit–I didn’t find a whole lot of play in England, either, although he’s right, it got more attention there than here.
This seems to be a very important development in cancer research, and it should have been front-page news. If you don’t agree, consider one interesting implication of the lung-cancer genome. According to Paddock’s story, the researchers found 23,000 mutation in the lung cancer cells. That works out to about one mutation per pack of cigarettes.
That’s so stunning I feel the need to say it again. A pack-a-day smoker adds one mutation to his genome every day. A lot of those land in places where there is no gene and they can do no damage. But would you like to fire a hole in your genome every day and hope for the best? Smokers are playing a more serious game of genetic Russian roulette than they realize.
That fact alone, aside form the importance of the basic science, should have attracted the attention of the news media.
As I said, I admit that I missed this story, too. Perhaps we’ve all written so many stories about so many genomes that we’re becoming jaded. We ought to struggle against that. We don’t want to miss too many like this.
- Paul Raeburn